Another thing is that people who have difficulty with ambiguity also score low on creativity -- which is a sub-grouping of the Big Five Personality Inventory trait of Openness

There's been a lot of research that points to the Big Five traits as being hard wired. That is, Openness is a function of ones temperament, and temperament is hardwired.

So what we might be looking at here is an overlapping Venn diagram of a low Openness score with a poor skill set of self-soothing along with low levels of positive interactions with "others." I'd think that working on any of those might have an effect.